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Perfluoroundecanoic acid

CAT: 0804-HY-W142432-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W142432-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS) . Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation[1][2][3][4].
CAS Number
2058-94-8
UNSPSC
12352211
Hazard Statement
H302+H332, H351, H360, H362, H372
Target
Akt; Arginase; Atg8/LC3; Autophagy; Biochemical Assay Reagents; ERK; mTOR; p62; TGF-beta/Smad; Wnt; β-catenin
Type
Reference compound
Related Pathways
Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Purity
99.85
Solubility
DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)F)F)F)F)F)F)O
Molecular Formula
C11HF21O2
Molecular Weight
564.09
Precautions
H302+H332, H351, H360, H362, H372
References & Citations
[1]Cui Z, et al. PFDA promotes cancer metastasis through macrophage M2 polarization mediated by Wnt/β-catenin signaling. Chemosphere. 2024 Aug;362:142758. |[2]Yan H, et al. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Toxicol Appl Pharmacol. 2021 Mar 15;415:115440. |[3]Bodin J, et al. Exposure to perfluoroundecanoic acid (PFUnDA) accelerates insulitis development in a mouse model of type 1 diabetes. Toxicol Rep. 2016 Aug 29;3:664-672. |[4]Ogunsuyi OM, et al. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Chemosphere. 2023 Oct;338:139491.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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