Azoramide

CAT: 0498-bs-82957C-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82957C-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Azoramide is a modulator of the unfolded protein response (UPR) .1 It improves endoplasmic reticulum (ER) protein folding and activates ER chaperone capacity to protect cells against ER stress. It displayed potent anti-diabetic activity in two mouse models by improving insulin sensitivity and pancreatic β cell function. Azoramide increased SERCA expression leading to enhanced calcium retention in the ER indicating calcium homeostasis as a possible mechanism for its anti-diabetic acitivty.
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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