Products for Research Use Only
RegisterLogin

Azoramide

CAT: 0804-HY-18705-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-18705-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR) . Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity[1][2].
CAS Number
932986-18-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bcl-2 Family; Caspase; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Azoramide.html
Concentration
10mM
Purity
99.57
Solubility
DMSO : ≥ 30 mg/mL
Smiles
CCCC(NCCC1=CSC(C2=CC=C(Cl)C=C2)=N1)=O
Molecular Formula
C15H17ClN2OS
Molecular Weight
308.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Fu S, et, al. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci Transl Med. 2015 Jun 17;7 (292) :292ra98.|[2]Ke M, et, al. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death Dis. 2020 Feb 18;11 (2) :130.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-107321-01Azosemide
HY-126664Azonafide-PEABA
HY-107321R-01Azosemide (Standard)
HY-126692Mal-VC-PAB-ABAEP-Azonafide

Alternative Products

CatalogName
C13332-01Azoramide
A16075-25Azoramide 25mg
A16075-10Azoramide 10mg
A16075-100Azoramide 100mg
A16075-50Azoramide 50mg
A16075-5Azoramide 5mg
A16075-200Azoramide 200mg
TBI4629-10MGAzoramide, UPR modulator

Popular Products