Azoramide

• Description:

  Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR) . Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Bcl-2 Family; Caspase; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/Azoramide.html

• Concentration:

  10mM

• Purity:

  99.57

• Solubility:

  DMSO : ≥ 30 mg/mL

• Smiles:

  CCCC(NCCC1=CSC(C2=CC=C(Cl)C=C2)=N1)=O

• Molecular Formula:

  C15H17ClN2OS

• Molecular Weight:

  308.83

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Fu S, et, al. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci Transl Med. 2015 Jun 17;7 (292) :292ra98.|[2]Ke M, et, al. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death Dis. 2020 Feb 18;11 (2) :130.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  932986-18-0