20 (S) -Hydroxycholesterol

CAT: 0498-bs-82906C-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82906C-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
20- (S) -Hydroxycholesterol is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic effects of 20- (S) -hydroxycholesterol have been shown to be mediated by activation of hedgehog signaling and expression of genes associated with Notch signaling.3 Activation of Hedgehog is mediated via binding of 20 (S) -hydroxycholesterol to Smoothened at a site distinct from the cyclopamine binding site.4,5
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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