7alpha-Hydroxycholesterol

• Background:

  Metabolite resulting from the action of cholesterol 7 alpha-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate-limiting step in the major pathway for bile acid synthesis in humans. A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3 Possible biomarker for cellular lipid peroxidation.4

• Conjugation:

  Unconjugated

• Buffer:

  White or pale yellow solid

• Storage Conditions:

  -20°C