PF-4136309

CAT: 0498-bs-82835C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82835C-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PF-4136309 (1341224-83-6) is a potent (hIC50 = 5.2 nM, mIC50 = 13 nM, rIC50 = 17 nM) and selective inhibitor of CCR2.1 PF-4136309 significantly decreased inflammatory monocytes in a mouse model of pancreatic cancer.2 In combination therapy with the FOLFIRINOX regimen, PF-4136309 reversed immune suppression in the tumor microenvironment causing an influx of tumor infiltrating lymphocytes leading to overall enhanced efficacy in a phase 1b study.3
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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A15127-2PF-4136309 2mg
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A15127-50PF-4136309 50mg
A15127-100PF-4136309 100mg

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