PF-06840003

CAT: 0498-bs-82880C-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82880C-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PF-06840003 (198474-05-4) is a potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1) .1 In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2 PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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Alternative Products

CatalogName
abx282999-01PF-06840003
A20807-25PF-06840003 25mg
462324-01PF-06840003 discontinued
A20807-5PF-06840003 5mg
A20807-10PF-06840003 10mg
A20807-100PF-06840003 100mg
HY-101111RPF-06840003 (Standard)
A20807-2PF-06840003 2mg
A20807-50PF-06840003 50mg
TBI4498-25MGPF-06840003, IDO1 inhibitor

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