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Alisertib

CAT: 0498-bs-82804C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82804C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Alisertib (MLN8237) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM) .1 It disrupts the Aurora A-Myc complex leading to Myc degradation2 in Myc amplified neuroblastomas3 and p53-mutant human hepatocellular carcinoma cell4. Alisertib has been found to induce apoptosis and autophagy in breast cancer5 and melanoma6 cells via suppression of activation of the p38 MAPK pathway.
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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