Products for Research Use Only
RegisterLogin

Alisertib (sodium)

CAT: 0804-HY-10971ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10971ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Alisertib (MLN 8237) sodium is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib sodium induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity[1][2][3].
CAS Number
1028486-06-7
Product Name Alternative
MLN 8237 (sodium)
UNSPSC
12352005
Target
Apoptosis; Aurora Kinase; Autophagy
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alisertib-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1OC)NC2=NC=C3CN=C(C4=CC(Cl)=CC=C4C3=N2)C5=C(C=CC=C5F)OC)O[Na]
Molecular Formula
C27H19ClFN4NaO4
Molecular Weight
540.91
References & Citations
[4]Manfredi MG, et al. Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays.Clin Cancer Res. 2011 Dec 15;17 (24) :7614-7624.|[1]Güllü G, et al. A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma Blood June 24, 2010 vol. 115 no. 25 5202-5213.|[2]Sloane DA, et al. Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237 ACS Chem. Biol., 2010, 5 (6), pp 563-576.|[3]Bavetsias V, et al. Aurora Kinase Inhibitors: Current Status and Outlook. Front Oncol. 2015 Dec 21;5:278.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Aurora A; Aurora B

Related Products

CatalogName
HY-10971-01Alisertib
HY-10971R-01Alisertib (Standard)
HY-W791754Paeonolsilate (sodium)
HY-W272811Camphorsulfonate (sodium)
HY-W094710-01Sodium diacetate
HY-W050026APhenylacetylglutamine (sodium)
HY-W009640AMofebutazone (sodium)
HY-22274-01DMPG (sodium)
HY-17474A-01Parecoxib (Sodium)
HY-D0208-01Fluorescein (sodium)

Alternative Products

CatalogName
MBS5799083Alisertib sodium
T71232-01Alisertib sodium hydrate
MBS3600137-01Alisertib
MBS385561-01MLN8237 (Alisertib)
MBS576776MLN8237(Alisertib)
C16135Alisertib (MLN8237)

Popular Products