Alisertib Sodium

• Target:

  Others|||Apoptosis|||Aurora Kinase|||Autophagy|||STAT

• Related Pathways:

  Autophagy|||Chromatin/Epigenetic|||Others|||Apoptosis|||Cell Cycle/Checkpoint|||Stem Cells|||JAK/STAT signaling

• Purity:

  0.9977

• Bioactivity:

  Alisertib Sodium (MLN 8237 Sodium) is a selective Aurora A inhibitor that causes G2/M phase arrest and chromosomal misalignment, leading to tumour cell apoptosis, and can also inhibit STAT3 Tyr705 phosphorylation, resulting in downregulation of c-Myc expression.

• Smiles:

  O=C(C1=CC=C(NC2=NC(C3=C(C(C4=C(OC)C=CC=C4F)=NC5)C=C(Cl)C=C3)=C5C=N2)C=C1OC)[O-].[Na+]

• Molecular Formula:

  C27H19ClFN4NaO4

• Molecular Weight:

  540.91

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1028486-06-7