Products for Research Use Only

A-438079 HCl

CAT: 0498-bs-82782C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82782C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A-438079 (899431-18-6) is a competitive P2X7 receptor antagonist (pIC50 = 6.9) .1 Displayed antinociceptive effects in a rat model of neuropathic pain.2 A-438079 prevented the LPS-induced release of IL-1ß and attenuated LPS-induced (via intrathecal lumbar injection) mechanical hyperalgesia in rat hindpaws.3 It prevented mechanical hyperalgesia following peripheral nerve injury.4 A-438079 protected against cerebral ischemia/reperfusion injury in a rat model via reduction of the neuroinflammatory response.5
Conjugation
Unconjugated
Buffer
White or off-white solid
Storage Conditions
-20°C