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A 438079 (Standard)

CAT: 0804-HY-15488R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15488R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A 438079 (Standard) is the analytical standard of A 438079. This product is intended for research and analytical applications. A 438079 is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
CAS Number
899507-36-9
UNSPSC
12352100
Target
P2X Receptor; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Neurological Disease
Smiles
ClC1=C(Cl)C(C2=NN=NN2CC3=CC=CN=C3)=CC=C1
Molecular Formula
C13H9Cl2N5
Molecular Weight
306.15
References & Citations
[1]McGaraughty S, et al. P2X7-related modulation of pathological nociception in rats. Neuroscience. 2007 Jun 8;146 (4) :1817-28.|[2]Mesuret G, et al. CNS Neurosci Ther. 2014 Jun;20 (6) :556-64.|[3]Marcellino D, et al. On the role of P2X (7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X (7) receptor antagonist A-438079. J Neural Transm (Vienna) . 2010 Jun;117 (6) :681-7.|[4]Martins JP, et al. The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice. Br J Pharmacol. 2012 Jan;165 (1) :183-96.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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