Irinotecan HCl

CAT: 0498-bs-82413C-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-82413C-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Irinotecan is a semi-synthetic derivative of camptothecin that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold) .3

Conjugation

Unconjugated

Buffer

Yellow solid

Storage Conditions

-20°C

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Catalog	Name
A5133-100	Irinotecan
sc-269253	(+) -Irinotecan
TRC-I767523-50MG	(+)-Irinotecan

Irinotecan HCl

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