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CAT: 0498-bs-82313C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82313C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM.1 Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2β.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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CatalogName
HY-12495A-01ISRIB

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