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trans-ISRIB

CAT: 0026-B1906-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B1906-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
trans-ISRIB is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation (IC₅₀ = 5 nM). Enhances spatial and fear-associated learning in mice and enhances cognitive function. Mechanism of action involves activation of eiF2β. Suppresses ER stress-induced inflammatory gene expression. Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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