ISRIB

• UNSPSC Description:

  ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research[1][2][3].

• Target Antigen:

  Biochemical Assay Reagents; Eukaryotic Initiation Factor (eIF)

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Cell Cycle/DNA Damage;Others

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/isrib.html

• Purity:

  98.58

• Solubility:

  DMSO : 6.25 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(NC1CCC(NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3

• Molecular Weight:

  451.34

• References & Citations:

  [1]Zyryanova AF, et al. ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B. Mol Cell. 2021 Jan 7;81(1):88-103.e6.|[2]Halliday M, et al. Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death Dis. 2015 Mar 5;6(3):e1672.|[3]Sidrauski C, et al. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. Elife. 2015 Feb 26;4:e05033.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  548470-11-7