Recombinant Human MetAP1

CAT: 1444-PEH1152-01Size: 10 µgDry Ice: YesHazardous: No
CAT#:1444-PEH1152-01Size:10 µg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G (2) /M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.
Product Name Alternative
Methionine aminopeptidase 1; MAP 1; MetAP 1; Peptidase M 1; METAP1
Accession Number
P53582
Host
E.coli
Endotoxin
<1 EU/µg as determined by LAL test.
Purity
Greater than 95% as determined by reducing SDS-PAGE
Form
Liquid
Molecular Weight
43.2 KDa
Shipping Conditions
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Formulation
Supplied as a 0.2 μm filtered solution of 20 mM Glycine, 10% Sucrose, 10% Glycerol, 0.02% Tween80, pH3.5.
Construct
Recombinant Human Methionine Aminopeptidase 1 is produced by our E.coli expression system and the target gene encoding Met1-Phe386 is expressed.
Species
Human

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