Recombinant Human SENP7

• Background:

  Sentrin-Specific Protease 7 (SENP7) acts as a SUMO-2/3-specific protease. SENP7 is likely to regulate the metabolism of poly-SUMO-2/3 rather than SUMO-1 conjugation in vivo. SENP7 has a restricted substrate specificity, and displaying paralogue-specific isopeptidase activity. The C-terminal catalytic domain of SENP7 depolymerized poly-SUMO-2 chains but does not have activity against poly-SUMO-1 chains. SENP7 also had isopeptidase activity against di-SUMO-2- and SUMO-2-modified RanGAP1 (Ran GTPase-activating protein 1) but had limited activity against SUMO-1-modified RanGAP1.

• Product Name Alternative:

  Sentrin-Specific Protease 7; SUMO-1-Specific Protease 2; Sentrin/SUMO-Specific Protease SENP7; SENP7; KIAA1707; SSP2; SUSP2

• Accession Number:

  Q9BQF6

• Host:

  E.coli

• Endotoxin:

  <1 EU/µg as determined by LAL test.

• Purity:

  Greater than 95% as determined by reducing SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  19.8 KDa

• Shipping Conditions:

  The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

• Storage Conditions:

  Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

• Formulation:

  Supplied as a 0.2 μm filtered solution of 20mM HEPES, 5% Glycerol, pH 7.4.

• Construct:

  Recombinant Human Sentrin-Specific Protease 7 is produced by our E.coli expression system and the target gene encoding Met695-Ala864 is expressed.

• Species:

  Human