Recombinant Human BID

CAT: 1444-PEH0152-01Size: 10 µgDry Ice: YesHazardous: No
CAT#:1444-PEH0152-01Size:10 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
BH3-Interacting Domain Death Agonist (BID) is a member of the Bcl-2 protein family which regulates outer mitochondrial membrane permeability. BID is a pro-apoptotic member that causes cytochrome c to be released from the mitochondria intermembrane space into the cytosol. Interaction of Bid with Bak causes altered mitochondrial membrane permeability. BID contains only the BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. It is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent, and also offer a new strategy for the treatment of acute renal failure associated with ischemia-reperfusion. BID receives direct inputs from a key regulator of the cell cycle arrest/DNA repair machinery (ATM), and therefore is an excellent candidate to coordinate genotoxic stress responses and apoptotic cell death. BID is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Deletion of BID inhibits carcinogenesis in the liver, although this genetic alteration promotes tumorigenesis in the myeloid cells. This is likely related to the function of BID to promote cell cycle progression into S phase. BID could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint.
Product Name Alternative
BH3-Interacting Domain Death Agonist; p22 BID; BID
Accession Number
P55957
Host
E.coli
Endotoxin
<1 EU/µg as determined by LAL test.
Purity
Greater than 95% as determined by reducing SDS-PAGE
Form
Liquid
Molecular Weight
21.99 KDa
Shipping Conditions
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Formulation
Supplied as a 0.2 μm filtered solution of 20mM PB, 100mM KCl, pH 7.4.
Construct
Recombinant Human BH3-Interacting Domain Death Agonist is produced by our E.coli expression system and the target gene encoding Met1-Asp195 is expressed.
Species
Human

Related Products

CatalogName
APRab07558-01BID Rabbit Polyclonal Antibody
AMM80978-01BID Mouse Monoclonal Antibody
AMRe21018-01BID Rabbit Monoclonal Antibody
APRab00175-01Bid Rabbit Polyclonal Antibody
AMRe02915-01Bid Rabbit Monoclonal Antibody
AMRe07557-01Bid (6Y3) Rabbit Monoclonal Antibody
AMM03565-01Bid (3C5) Mouse Monoclonal Antibody
APRab04318-01BID (phospho Ser78) Rabbit Polyclonal Antibody
EH26974Human Bid (BH3 Interacting Domain Death Agonist) ELISA Kit
EM23971Mouse Bid (BH3 Interacting Domain Death Agonist) ELISA Kit

Alternative Products

CatalogName
P0015Recombinant Human AND
MBS7612987-01Recombinant Human WAS
CC014-010Recombinant Human Apoliprotein-J (Clusterin Human Recombinant)
054-85TWEAK, recombinant / TNFSF12, recombinant (Human)
PT_39973-01Beta 2 Microglobulin Human Recombinant (B2M Human Recombinant)
PT_40053-01C-Reactive Protein Human Recombinant (CRP Human Recombinant)
P10106-01Recombinant Human FSH alpha+Recombinant Human FSH beta
MBS7621442-01Recombinant Human BTN3A2
MBS954800-01Recombinant Human Angiotensinogen
MBS962962-01Recombinant Human Calmodulin

Popular Products