Recombinant Human UBE2B

• Background:

  Ubiquitin-Conjugating Enzyme E2 B (UBE2B) belongs to the ubiquitin-conjugating enzyme family. UBE2B can catalyze the covalent attachment of ubiquitin to other proteins, and is essential for the multi-ubiquitination and degradation of N-end rule substrates. UBE2B is indispensability for postreplication repair of UV-damaged DNA and may be involved in neurite outgrowth.Additionally, UBE2B may have a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia.

• Product Name Alternative:

  Ubiquitin-Conjugating Enzyme E2 B; RAD6 Homolog B; HR6B; hHR6B; Ubiquitin Carrier Protein B; Ubiquitin-Conjugating Enzyme E2-17 kDa; Ubiquitin-Protein Ligase B; UBE2B; RAD6B

• Accession Number:

  P63146

• Host:

  E.coli

• Endotoxin:

  <1 EU/µg as determined by LAL test.

• Purity:

  Greater than 95% as determined by reducing SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  17.5 KDa

• Shipping Conditions:

  The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

• Storage Conditions:

  Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

• Formulation:

  Supplied as a 0.2 μm filtered solution of 10mM HEPES, pH 7.5.

• Construct:

  Recombinant Human Ubiquitin-Conjugating Enzyme E2 B is produced by our E.coli expression system and the target gene encoding Met1-Ser152 is expressed.

• Species:

  Human