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XST-14

CAT: 0804-HY-137506-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137506-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects[1].
CAS Number
2607143-50-8
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Apoptosis; CaMK; p38 MAPK; TGF-β Receptor; ULK
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway; Neuronal Signaling; Protein Tyrosine Kinase/RTK; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xst-14.html
Purity
99.26
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(OC)C1=CC2=C(OC(C)C)C=C(OC(C)C)C=C2N1
Molecular Formula
C16H21NO4
Molecular Weight
291.34
References & Citations
[1]Si-Tu Xue, et al. The role of the key autophagy kinase ULK1 in hepatocellular carcinoma and its validation as a treatment target . Autophagy. 2020 Oct;16 (10) :1823-1837.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CaMK II; ULK1

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