Products for Research Use Only
RegisterLogin

Bfl-1 Antibody

CAT: 0223-3875-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-3875-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Bfl-1 Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells. At least two isoforms of Bfl-1 are known to exist.
NCBI Gene ID
597
Swiss Prot
Q16548
Accession Number
NP_004040
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Neuroscience
Purification
Bfl-1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1305 - Human Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (87%)
Buffer
Bfl-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Bfl-1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of Bfl-1 are known to exist; this antibody will detect both isoforms.
Symbol
BCL2A1
NCBI Official Name
BCL2-related protein A1
NCBI Organism
Homo sapiens
Background Reference 01
Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
Background Reference 02
Choi SS, Park IC, Yun JW, et al. A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. Oncogene 1995; 11:1693-8.
Background Reference 03
Kim JK, Kim KD, Lee E, et al. Up-regulation of Bfl-1/A1 via NF-κ B activation in cisplatin-resistant human bladder cancer cell line. Cancer Lett. 2004; 212:61-70.
Background Reference 04
Zhang H, Cowan-Jacob SW, Simonen M, et al. Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells. J. Biol. Chem.2000; 275:11092-9.
Other Product Names
Bfl-1 Antibody: GRS, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5, GRS, Bcl-2-related protein A1, Bcl-2-like protein 5, Bcl2-L-5
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4757840
Physical Properties
Liquid

Related Products

CatalogName
3875PBfl-1 Peptide
3873PBfl-1 Peptide
36-149BAFF Antibody [1-35-1]
33-439CD99 Antibody [HO36-1.1]
33-215TTF-1 Antibody [8G7G3/1]
34-055TIA-1 Antibody [TRIA1-1]
33-951Arginase 1 Antibody [T1ARG-1]
33-860PD-1 Antibody [PD203-1]
33-881MUC-1 Antibody [MCN01-1]
79-773Oct-1 Antibody

Alternative Products

CatalogName
MBS9405800-01Bfl-1 Antibody
APR06415GPolyclonal Bfl-1 Antibody
E90134A1/Bfl-1 Antibody
24435Bfl Antibody
C21611-100uLA1/Bfl-1 Antibody [N2F22]
A03850-1Anti-Bfl-1 BCL2A1 Antibody
C19506-50uLA1/Bfl-1 Antibody [D21F14]
CST 64310SA1/Bfl-1 (E4P2I) Rabbit Monoclonal Antibody
CST 14093TA1/Bfl-1 (D1A1C) Rabbit Monoclonal Antibody
CST 24951TA1/Bfl-1 (E3U2F) Rabbit Monoclonal Antibody

Popular Products