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Philanthotoxin 74 (diTFA)

CAT: 0804-HY-104020BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-104020BSize:1 Each
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Description
Philanthotoxin 74 (PhTx 74) diTFA is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively[1][2].
CAS Number
401601-12-5
Product Name Alternative
PhTx 74 (diTFA)
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/philanthotoxin-74-ditfa.html
Smiles
O=C(NCCCCCCCNCCCCN)[C@@H](NC(CCC)=O)CC1=CC=C(O)C=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Molecular Formula
C28H44F6N4O7
Molecular Weight
662.66
References & Citations
[1]Poulsen MH, et al. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol Pharmacol. 2014 Feb;85 (2) :261-8.|[2]Kromann H, et al. Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors. J Med Chem. 2002 Dec 19;45 (26) :5745-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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