PA-8

• Description :

  PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo.

• Stability :

  ≥ 2 years

• Purity :

  >98% (HPLC)

• Weight :

  342.35

• Molecular Formula :

  C17H18N4O4

• Notes :

  Research use only, not for human use.

• Receptor :

  PACAP

• CAS Number :

  878437-15-1