PA-8

CAT: 1410-M35242-01Size: 1 gDry Ice: NoHazardous: No
CAT#:1410-M35242-01Size:1 g
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Description
PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo.
CAS Number
878437-15-1
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
342.35
Molecular Formula
C17H18N4O4
Notes
Research use only, not for human use.
Receptor
PACAP

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