PA-8

• Target:

  PACAP

• Related Pathways:

  GPCR/G Protein

• Purity:

  0.9764

• Bioactivity:

  PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo.

• Smiles:

  COc1cc(ccc1OCC=C)C1CC(=O)Nc2nc(N)[nH]c(=O)c12

• Molecular Formula:

  C17H18N4O4

• Molecular Weight:

  342.35

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  878437-15-1