CC-99677

CAT: 1410-M35108-01Size: 1 gDry Ice: NoHazardous: No
CAT#:1410-M35108-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.CC-99677 in Rat experiments demonstrated potency in both biochemical (IC 50 =156.3 nM) and cellular assays (EC 50 =89 nM) .
CAS Number
1887069-10-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
469.94
Molecular Formula
C22H20ClN5O3S
Notes
Research use only, not for human use.
Receptor
MAPK | HSP

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