CC-99677

• Description:

  CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.CC-99677 in Rat experiments demonstrated potency in both biochemical (IC 50 =156.3 nM) and cellular assays (EC 50 =89 nM) .

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  469.94

• Molecular Formula:

  C22H20ClN5O3S

• Notes:

  Research use only, not for human use.

• Receptor:

  MAPK | HSP

• CAS Number:

  1887069-10-4