SB-657510

CAT: 1410-M33117-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No

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CAT#:1410-M33117-02Size:1 mL x 10 mM in DMSO

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Description

SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators, such as adhesion molecules, in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models.

CAS Number

474960-44-6

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

505.81

Molecular Formula

C19H22BrClN2O5S

Notes

Research use only, not for human use.

Receptor

Neurotensin Receptor

Chemical Information

SB 657510

a urotensin II antagonist

CAS Number	474960-44-6
PubChem CID	11272107
IUPAC Name	2-bromo-N-[4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxyphenyl]-4,5-dimethoxybenzenesulfonamide
Molecular Formula	C19H22BrClN2O5S
Molecular Weight	505.8
XLogP	3.9
Topological Polar Surface Area	85.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Heavy Atom Count	29
Formal Charge	0
Complexity	637

SMILES

CN1CC[C@H](C1)OC2=C(C=CC(=C2)NS(=O)(=O)C3=C(C=C(C(=C3)OC)OC)Br)Cl

InChI

InChI=1S/C19H22BrClN2O5S/c1-23-7-6-13(11-23)28-16-8-12(4-5-15(16)21)22-29(24,25)19-10-18(27-3)17(26-2)9-14(19)20/h4-5,8-10,13,22H,6-7,11H2,1-3H3/t13-/m1/s1

InChIKey

KQCZCINJGIRLCD-CYBMUJFWSA-N

Chemical Structure

2D Structure

CAS: 474960-44-6

CID: 11272107

Formula: C19H22BrClN2O5S

MW: 505.8

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	505.8
XLogP3	3.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	504.01213
Monoisotopic Mass	504.01213
Topological Polar Surface Area	85.5 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	637
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Catalog	Name
465913-01	SB 657510
MBS5753873	SB-657510
GTR19153626-01	SB-269970, SB 269970
217783	SB-277011-A Dihydrochloride (SB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A)
366911-01	SB 216763 (SB216763, SB-216763, SCHEMBL30251)
BA5664-5	SB-649868
BA8268-10	SB-435495
B6710-10	SB 218795
BA5318-1	SB-209670
B8200-5	SB 225002

SB-657510

Chemical Information

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