SB-657510

• Description:

  SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators, such as adhesion molecules, in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  505.81

• Molecular Formula:

  C19H22BrClN2O5S

• Notes:

  Research use only, not for human use.

• Receptor:

  Neurotensin Receptor

• CAS Number:

  474960-44-6