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SB-657510

CAT: 1410-M33117-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M33117-06Size:100 mg
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Description
SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators, such as adhesion molecules, in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models.
CAS Number
474960-44-6
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
505.81
Molecular Formula
C19H22BrClN2O5S
Notes
Research use only, not for human use.
Receptor
Neurotensin Receptor

Chemical Information

SB 657510

a urotensin II antagonist

CAS Number474960-44-6
PubChem CID11272107
IUPAC Name2-bromo-N-[4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxyphenyl]-4,5-dimethoxybenzenesulfonamide
Molecular FormulaC19H22BrClN2O5S
Molecular Weight505.8
XLogP3.9
Topological Polar Surface Area85.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count29
Formal Charge0
Complexity637
SMILES
CN1CC[C@H](C1)OC2=C(C=CC(=C2)NS(=O)(=O)C3=C(C=C(C(=C3)OC)OC)Br)Cl
InChI
InChI=1S/C19H22BrClN2O5S/c1-23-7-6-13(11-23)28-16-8-12(4-5-15(16)21)22-29(24,25)19-10-18(27-3)17(26-2)9-14(19)20/h4-5,8-10,13,22H,6-7,11H2,1-3H3/t13-/m1/s1
InChIKey
KQCZCINJGIRLCD-CYBMUJFWSA-N
Chemical Structure
2D Structure
2D structure of SB 657510
CAS: 474960-44-6
CID: 11272107
Formula: C19H22BrClN2O5S
MW: 505.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight505.8
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass504.01213
Monoisotopic Mass504.01213
Topological Polar Surface Area85.5 Ų
Heavy Atom Count29
Formal Charge0
Complexity637
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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