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ARN-21934

CAT: 1410-M28108-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:1410-M28108-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ARN-21934 is a potent and selective inhibitor for human topoisomerase II α and topoisomerase II β. ARN-21934 (IC50 = 2 μM) inhibits DNA relaxation as compared to the anticancer agent Etoposide (IC50=120 μM) .
CAS Number
2230854-93-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
360.46
Molecular Formula
C21H24N6
Notes
Research use only, not for human use.
Receptor
——

Chemical Information

N4-(4-(dimethylamino)phenyl)-2-(pyridin-4-yl)-5,6,7,8-tetrahydroquinazoline-4,6-diamine
CAS Number2230854-93-8
PubChem CID135150944
IUPAC Name4-N-[4-(dimethylamino)phenyl]-2-pyridin-4-yl-5,6,7,8-tetrahydroquinazoline-4,6-diamine
Molecular FormulaC21H24N6
Molecular Weight360.5
XLogP2.6
Topological Polar Surface Area80
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity458
SMILES
CN(C)C1=CC=C(C=C1)NC2=NC(=NC3=C2CC(CC3)N)C4=CC=NC=C4
InChI
InChI=1S/C21H24N6/c1-27(2)17-6-4-16(5-7-17)24-21-18-13-15(22)3-8-19(18)25-20(26-21)14-9-11-23-12-10-14/h4-7,9-12,15H,3,8,13,22H2,1-2H3,(H,24,25,26)
InChIKey
CKXSRLUXTFDZCF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N4-(4-(dimethylamino)phenyl)-2-(pyridin-4-yl)-5,6,7,8-tetrahydroquinazoline-4,6-diamine
CAS: 2230854-93-8
CID: 135150944
Formula: C21H24N6
MW: 360.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight360.5
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass360.20624479
Monoisotopic Mass360.20624479
Topological Polar Surface Area80 Ų
Heavy Atom Count27
Formal Charge0
Complexity458
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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