ARN 14494

• Target:

  NO Synthase|||COX|||Apoptosis|||Interleukin|||Others

• Related Pathways:

  Apoptosis|||Immunology/Inflammation|||Neuroscience|||Others

• Bioactivity:

  ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM) . ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against ?-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.

• Smiles:

  O=C1N(C=2C(C1)=CC(C(NC)=O)=CC2)C3CCN(CC(=O)N4CC5C(C4)CCC5)CC3

• Molecular Formula:

  C24H32N4O3

• Molecular Weight:

  424.54

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1037837-27-6