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IFSP1

CAT: 1410-M22418-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M22418-06Size:100 mg
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Description
IFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R) -RSL3.iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM.
CAS Number
150651-39-1
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
323.35
Molecular Formula
C20H13N5
Notes
Research use only, not for human use.
Receptor
Ferroptosis

Chemical Information

13-Amino-11-(4-methylphenyl)-1,8-diazatricyclo[7.4.0.0,2,7]trideca-2,4,6,8,10,12-hexaene-10,12-dicarbonitrile

IFSP1 is a member of the class of pyridobenzimidazoles that is pyrido[1,2-a]benzimidazole substituted by amino, cyano, 4-methylphenyl, and cyano groups at positions 1, 2, 3 and 4, respectively. It is a potent inhibitor of ferroptosis suppressor protein 1 (FSP1) with EC50 of 103 nM. It induces ferroptosis in GPX4 knockout cells that overexpress FSP1. It has a role as a ferroptosis inducer, a ferroptosis suppressor protein 1 inhibitor and an antineoplastic agent. It is a pyridobenzimidazole, a nitrile, a member of toluenes, an aromatic amine and a primary amino compound.

CAS Number150651-39-1
PubChem CID699043
IUPAC Name1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
Molecular FormulaC20H13N5
Molecular Weight323.3
XLogP4.8
Topological Polar Surface Area90.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count25
Formal Charge0
Complexity592
SMILES
CC1=CC=C(C=C1)C2=C(C3=NC4=CC=CC=C4N3C(=C2C#N)N)C#N
InChI
InChI=1S/C20H13N5/c1-12-6-8-13(9-7-12)18-14(10-21)19(23)25-17-5-3-2-4-16(17)24-20(25)15(18)11-22/h2-9H,23H2,1H3
InChIKey
FNESYDFRCQEEKA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 13-Amino-11-(4-methylphenyl)-1,8-diazatricyclo[7.4.0.0,2,7]trideca-2,4,6,8,10,12-hexaene-10,12-dicarbonitrile
CAS: 150651-39-1
CID: 699043
Formula: C20H13N5
MW: 323.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight323.3
XLogP34.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass323.11709544
Monoisotopic Mass323.11709544
Topological Polar Surface Area90.9 Ų
Heavy Atom Count25
Formal Charge0
Complexity592
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B2676-5iFSP1
A22277-10IFSP1 10mg
A22277-5IFSP1 5mg
A22277-25IFSP1 25mg

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