IFSP1

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Description

IFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R) -RSL3.iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM.

CAS Number

150651-39-1

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

323.35

Molecular Formula

C20H13N5

Notes

Research use only, not for human use.

Receptor

Ferroptosis

Chemical Information

13-Amino-11-(4-methylphenyl)-1,8-diazatricyclo[7.4.0.0,2,7]trideca-2,4,6,8,10,12-hexaene-10,12-dicarbonitrile

IFSP1 is a member of the class of pyridobenzimidazoles that is pyrido[1,2-a]benzimidazole substituted by amino, cyano, 4-methylphenyl, and cyano groups at positions 1, 2, 3 and 4, respectively. It is a potent inhibitor of ferroptosis suppressor protein 1 (FSP1) with EC50 of 103 nM. It induces ferroptosis in GPX4 knockout cells that overexpress FSP1. It has a role as a ferroptosis inducer, a ferroptosis suppressor protein 1 inhibitor and an antineoplastic agent. It is a pyridobenzimidazole, a nitrile, a member of toluenes, an aromatic amine and a primary amino compound.

CAS Number	150651-39-1
PubChem CID	699043
IUPAC Name	1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
Molecular Formula	C20H13N5
Molecular Weight	323.3
XLogP	4.8
Topological Polar Surface Area	90.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Heavy Atom Count	25
Formal Charge	0
Complexity	592

SMILES

CC1=CC=C(C=C1)C2=C(C3=NC4=CC=CC=C4N3C(=C2C#N)N)C#N

InChI

InChI=1S/C20H13N5/c1-12-6-8-13(9-7-12)18-14(10-21)19(23)25-17-5-3-2-4-16(17)24-20(25)15(18)11-22/h2-9H,23H2,1H3

InChIKey

FNESYDFRCQEEKA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 150651-39-1

CID: 699043

Formula: C20H13N5

MW: 323.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	323.3
XLogP3	4.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	323.11709544
Monoisotopic Mass	323.11709544
Topological Polar Surface Area	90.9 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	592
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
B2676-5	iFSP1
A22277-10	IFSP1 10mg
A22277-5	IFSP1 5mg
A22277-25	IFSP1 25mg

IFSP1

Chemical Information

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