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MK-0893

CAT: 1410-M16326-01Size: 1 EachDry Ice: NoHazardous: No
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Description
A potent, selective, reversible and competitive antagonist of glucagon receptor with high binding affinity (IC (=50=6.6 nM) and functional cAMP activity (IC50=15.7 nM) .
CAS Number
870823-12-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
588.4805
Molecular Formula
C32H27Cl2N3O4
Notes
Research use only, not for human use.
Receptor
Glucagon Receptor

Chemical Information

Mk-0893

MK0893 has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Diabetes Mellitus, Type 2.

CAS Number870823-12-4
PubChem CID11570626
IUPAC Name3-[[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acid
Molecular FormulaC32H27Cl2N3O4
Molecular Weight588.5
XLogP6.8
Topological Polar Surface Area93.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Heavy Atom Count41
Formal Charge0
Complexity877
SMILES
C[C@@H](C1=CC=C(C=C1)C(=O)NCCC(=O)O)N2C(=CC(=N2)C3=CC(=CC(=C3)Cl)Cl)C4=CC5=C(C=C4)C=C(C=C5)OC
InChI
InChI=1S/C32H27Cl2N3O4/c1-19(20-3-5-21(6-4-20)32(40)35-12-11-31(38)39)37-30(18-29(36-37)25-14-26(33)17-27(34)15-25)24-8-7-23-16-28(41-2)10-9-22(23)13-24/h3-10,13-19H,11-12H2,1-2H3,(H,35,40)(H,38,39)/t19-/m0/s1
InChIKey
DNTVJEMGHBIUMW-IBGZPJMESA-N
Chemical Structure
2D Structure
2D structure of Mk-0893
CAS: 870823-12-4
CID: 11570626
Formula: C32H27Cl2N3O4
MW: 588.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight588.5
XLogP36.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass587.1378617
Monoisotopic Mass587.1378617
Topological Polar Surface Area93.5 Ų
Heavy Atom Count41
Formal Charge0
Complexity877
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-50663-01MK 0893
MBS3606321-01MK-0893
A11495-5MK 0893 5mg
A11495-25MK 0893 25mg
A11495-50MK 0893 50mg
A11495-10MK 0893 10mg
A11495-100MK 0893 100mg
324068-01MK
167912Midkine (MK, MK1, MK-1, MK 1) discontinued
MBS131426MK-4101 (MK 4101; MK4101)

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