MK 8776

CAT: 1410-M16431-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:1410-M16431-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MK 8776 (SCH 900776) is a potent and functionally selective CHK1 inhibitor (IC50=3 nM) with minimal intrinsic antagonistic properties.

CAS Number

891494-63-6

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

376.25

Molecular Formula

C15H18BrN7

Notes

Research use only, not for human use.

Receptor

CDK2|Chk1|Chk2

Chemical Information

Sch-900776

Sch 900776 has been used in trials studying the treatment of Neoplasms, Hodgkin Disease, Adult Erythroleukemia, Lymphoma, Non-Hodgkin, and Myelogenous Leukemia, Acute, among others.

CAS Number	891494-63-6
PubChem CID	46239015
IUPAC Name	6-bromo-3-(1-methylpyrazol-4-yl)-5-[(3R)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidin-7-amine
Molecular Formula	C15H18BrN7
Molecular Weight	376.25
XLogP	0.8
Topological Polar Surface Area	86.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Heavy Atom Count	23
Formal Charge	0
Complexity	425

SMILES

CN1C=C(C=N1)C2=C3N=C(C(=C(N3N=C2)N)Br)[C@@H]4CCCNC4

InChI

InChI=1S/C15H18BrN7/c1-22-8-10(6-19-22)11-7-20-23-14(17)12(16)13(21-15(11)23)9-3-2-4-18-5-9/h6-9,18H,2-5,17H2,1H3/t9-/m1/s1

InChIKey

GMIZZEXBPRLVIV-SECBINFHSA-N

Chemical Structure

2D Structure

CAS: 891494-63-6

CID: 46239015

Formula: C15H18BrN7

MW: 376.25

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	376.25
XLogP3	0.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	375.08071
Monoisotopic Mass	375.08071
Topological Polar Surface Area	86.1 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	425
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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M16688-01	MK-4101
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M15329-01	MK-212
M14568-01	MK-0752
M12381-01	MK-6169
M11576-01	MK-8825
M10761-01	MK-1064
M10626-01	MK-8353
M10202-01	MK-4074
M10091-01	MK-3577

Alternative Products

Catalog	Name
GTR19160886-01	MK 8776
RKB49463-01	MK-8776 (SCH 900776)
A8477-50	MK-8776 (SCH-900776)
MBS386148-01	SCH 900776 (MK-8776)
bs-6464C-01	MK-8776 S-isomer
A11167-25	SCH 900776 (MK-8776) 25mg
A11167-1	SCH 900776 (MK-8776) 1mg
A11167-2	SCH 900776 (MK-8776) 2mg
NBP3-20355-20ug	Mouse Monoclonal Occludin Antibody (rOCLN/8776)

MK 8776

Chemical Information

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