Pro-GA

CAT: 0804-HY-171030-01Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-171030-01Size:2 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Pro-GA is a γ-Glutamylcyclotransferase (GGCT) inhibitor and a cell-permeable diester-type pro-drug with anticancer activity, GGCT is a key enzyme in glutathione metabolism and is involved in the ferroptosis pathway. Pro-GA exhibits an IC50 of 57 μM against the bladder cancer cell line T24 and can be utilized in cancer research[1].

CAS Number

2222067-12-9

UNSPSC

12352211

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pro-ga.html

Purity

97.86

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(OC)CCCC(N[C@@H](C)C(OCOC(C)=O)=O)=O

Molecular Formula

C12H19NO7

Molecular Weight

289.28

References & Citations

[1]Hanada E, et al. Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth. Anticancer Res. 2019 Apr;39 (4) :1893-1898.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Alternative Products

Catalog	Name
GTR19241259-01	Pro-GA
abx085044-01	GA-PEG-GA
HO012012-1K-01	GA-PEG-GA, 1K
HO012012-10K-01	GA-PEG-GA, 10K
HO012012-5K-01	GA-PEG-GA, 5K
HO012012-20K-01	GA-PEG-GA, 20K
HO012012-2K-01	GA-PEG-GA, 2K
HO012012-3.4K-01	GA-PEG-GA, 3.4K
BA9120-50	GA-017
abx085020-01	MPEG-GA

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