Pro-GA

• Description:

  Pro-GA is a γ-Glutamylcyclotransferase (GGCT) inhibitor and a cell-permeable diester-type pro-drug with anticancer activity, GGCT is a key enzyme in glutathione metabolism and is involved in the ferroptosis pathway. Pro-GA exhibits an IC50 of 57 μM against the bladder cancer cell line T24 and can be utilized in cancer research[1].

• UNSPSC:

  12352211

• Target:

  Ferroptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pro-ga.html

• Purity:

  97.86

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(OC)CCCC(N[C@@H](C)C(OCOC(C)=O)=O)=O

• Molecular Formula:

  C12H19NO7

• Molecular Weight:

  289.28

• References & Citations:

  [1]Hanada E, et al. Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth. Anticancer Res. 2019 Apr;39 (4) :1893-1898.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2222067-12-9]