Pro-GA

• Description :

  Pro-GA is a γ-Glutamylcyclotransferase (GGCT) inhibitor and a cell-permeable diester-type pro-drug with anticancer activity, GGCT is a key enzyme in glutathione metabolism and is involved in the ferroptosis pathway. Pro-GA exhibits an IC50 of 57 μM against the bladder cancer cell line T24 and can be utilized in cancer research[1].

• UNSPSC :

  12352211

• Target :

  Ferroptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pro-ga.html

• Purity :

  97.86

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(OC)CCCC(N[C@@H](C)C(OCOC(C)=O)=O)=O

• Molecular Formula :

  C12H19NO7

• Molecular Weight :

  289.28

• References & Citations :

  [1]Hanada E, et al. Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth. Anticancer Res. 2019 Apr;39 (4) :1893-1898.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2222067-12-9]