Feline CXCL10 (IP-10) Recombinant Protein

• Background:

  CXCL10, also known as Interferon gamma-induced protein 10 or small-inducible cytokine B10, is a member of the C-X-C chemokine family. CXCL10 is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative) . ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL10 elicits its effects by binding to the cell surface chemokine receptor CXCR3.

• Description:

  The Feline CXCL10 yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Feline CXCL10 applications are for cell culture, ELISA standard, and Western Blot Control. The Feline CXCL10 yeast-derived recombinant protein can be purchased in multiple sizes. Feline CXCL10 Specifications: (Molecular Weight: 8.7 kDa) (Amino Acid Sequence: IPLSRTPRCT CIKISELSVN LRSLEKLEVI PASHFCPRVE IIATMKKNGE KTCLNPESKT IKNLVKAISK ERSKRSP (77) ) (Gene ID: 101100131) . For research use only.

• Applications:

  Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control

• Homology:

  Acinonyx jubatus (cheetah), Felis catus (domestic cat), Lynx canadensis (Canada lynx), Lynx pardinus (Spanish lynx), Panthera leo (lion), Panthera pardus (leopard), Panthera tigris altaica (Amur tiger), Panthera uncia (snow leopard), Puma concolor (puma)

• Storage Temperature:

  -20°C