IP-10 (CXCL10)

• Description :

  IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant rat IP-10 is an 8.6 kDa protein consisting of 77 amino acids including the four conserved cysteine residues present in CXC chemokines.

• Synonyms :

  Gamma-Interferon inducible protein 10, CXCL10, crg-2

• NCBI Gene ID :

  245920

• UniProt :

  P48973

• Accession Number :

  NP_620789.1

• Accession Number mRNA :

  NM_139089.1

• Chromosomal Location :

  14p22

• Reactivity :

  Rat

• Cross Reactivity :

  Rat, Human

• Sequence :

  IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 10.0-50.0 ng/ml.

• Length :

  77

• Form :

  Lyophilized

• Molecular Weight :

  8.6 kDa

• Host or Source :

  E. coli