Bovine CTLA-4 Recombinant Protein

• Background:

  CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. It is a member of the Ig gene superfamily and along with its homologue, CD28, is a B7 binding protein. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. Alternatively spliced mRNA generates a soluble form, called sCTLA-4. Whereas low levels of sCTLA-4 are detected in normal human serum, increased/high serum levels are observed in several autoimmune diseases.

• Description:

  The Bovine sCTLA-4 yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Bovine sCTLA-4 applications are for cell culture, ELISA standard, and Western Blot Control. Bovine sCTLA-4 yeast-derived recombinant protein can be purchased in multiple sizes. Bovine sCTLA-4 Specifications: (Molecular Weight: 13.8 kDa) (Amino Acid Sequence: FSKGMNVTQP PVVLASSRGV ASFSCEYESS GKADEVRVTV LREAGSQVTE VCAGTYMVED ELTFLDDSTC IGTSRGNKVN LTIQGLRAMD TGLYVCKVEL MYPPPYYVGI GNGTQIYVID PEPCPDSD (128) ) (Gene ID: 281732) . For research use only.

• Applications:

  Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control

• Homology:

  Bison bison bison (American buffalo), Bos grunniens (domestic yak), Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle), Bubalus bubalis (water buffalo), Bubalus carabanensis (carabao)

• Storage Temperature:

  -20°C