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CTLA 4 Recombinant Protein

CAT: 0223-96-219Size: 0.2 mgDry Ice: NoHazardous: No
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CAT#:0223-96-219Size:0.2 mg
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Background
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
CAS Number
9000-83-3
NCBI Gene ID
1493
Swiss Prot
P16410
Accession Number
NP_005205.2
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Purity
>98% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
40 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Cytotoxic T-lymphocyte-associated protein 4
NCBI Organism
Homo sapiens
Background Reference 01
Waterhouse P, et al., 1995, Science 270 (5238) : 985–8.
Background Reference 02
Magistrelli G, et al., 1999. Eur. J. Immunol. 29 (11) : 3596–602.
Background Reference 03
Rudd, CE. et al., 2009, Immunol. Rev. 229 (1) : 12-26.
Other Product Names
CTLA4, CD152, CELIAC3, GRD4, GSE, ICOS, IDDM12
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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