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Mouse CTLA-4 Recombinant Protein

CAT: 0908-RP2188MSize: 5 µgDry Ice: NoHazardous: No
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CAT#:0908-RP2188MSize:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. It is a member of the Ig gene superfamily and along with its homologue, CD28, is a B7 binding protein. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. Alternatively spliced mRNA generates a soluble form, called sCTLA-4. Whereas low levels of sCTLA-4 are detected in normal human serum, increased/high serum levels are observed in several autoimmune diseases.
Description
The Mouse CTLA-4 yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Mouse CTLA-4 applications are for cell culture, ELISA standard, and Western Blot Control. Mouse CTLA-4 yeast-derived recombinant protein can be purchased in multiple sizes. Mouse CTLA-4 Specifications: (Molecular Weight: 13.9 kDa) (Amino Acid Sequence: EAIQVTQPSV VLASSHGVAS FPCEYSPSHN TDEVRVTVLR QTNDQMTEVC ATTFTEKNTV GFLDYPFCSG TFNESRVNLT IQGLRAVDTG LYLCKVELMY PPPYFVGMGN GTQIYVIDPE PCPDSD (126) ) (Gene ID: 12477) . For research use only.
Applications
Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
Homology
Mus musculus (house mouse)
Purity
>98% as visualized by SDS-PAGE analysis.
Molecular Weight
13.9kDa
Storage Temperature
-20°C

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