Bovine CTLA-4 Polyclonal Antibody

• Background:

  CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. It is a member of the Ig gene superfamily and along with its homologue, CD28, is a B7 binding protein. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. Alternatively spliced mRNA generates a soluble form, called sCTLA-4. Whereas low levels of sCTLA-4 are detected in normal human serum, increased/high serum levels are observed in several autoimmune diseases.

• Description:

  The Bovine CTLA-4 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Bovine CTLA-4 ELISA. The Bovine CTLA-4 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine CTLA-4 - Strong) (Cynomolgus Monkey CTLA-4 - None) (Human CTLA-4 - None) (Rabbit CTLA-4 - None) (Swine CTLA-4 - Weak) . For research use only.

• Host:

  Rabbit

• Label:

  Unconjugated

• Applications:

  ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot

• Purification:

  Antigen-affinity

• Homology:

  Bison bison bison (American buffalo), Bos grunniens (domestic yak), Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle), Bubalus bubalis (water buffalo), Bubalus carabanensis (carabao)

• Storage Temperature:

  2°C to 8°C

• Scientific Category:

  Antibody