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HSD17B13-IN-3

CAT: 0804-HY-156736-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-156736-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HSD17B13-IN-3 (compound 2) is a potent hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor with IC50s of 0.38 μM and 0.45 μM in biochemical assays using both β-estradiol or Leukotriene B4 (LTB4) as substrate and NAD+ as cofactor. HSD17B13-IN-3 shows low cell penetration[1].
CAS Number
313259-88-0
UNSPSC
12352005
Target
17β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsd17b13-in-3.html
Concentration
10mM
Purity
99.78
Solubility
DMSO : 260 mg/mL (ultrasonic)
Smiles
CC1=C(S(C2=CC=C(C)C=C2)(=O)=O)C=C(C)C=C1S(=O)(NC3=CC=C(C(O)=O)C=C3)=O
Molecular Formula
C22H21NO6S2
Molecular Weight
459.54
References & Citations
[1]Liu S, et, al. Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13. Nat Commun. 2023 Aug 24;14 (1) :5158.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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