6-Phosphogluconic acid (trisodium)

6-Phosphogluconic acid (trisodium)

• CAS Number: 53411-70-4
• UNSPSC Description: 6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2].
• Target Antigen: Endogenous Metabolite
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/6-phosphogluconic-acid-trisodium.html
• Purity: 98.0
• Solubility: H2O : 125 mg/mL (ultrasonic)
• Smiles: O=C(O[Na])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O[Na])(O[Na])=O
• Molecular Weight: 342.08
• References & Citations: [1]Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52.|[2]Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported