Citric acid (trisodium)

• UNSPSC Description:

  Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice[1][2][3].

• Target Antigen:

  Apoptosis; Endogenous Metabolite

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Metabolic Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/citric-acid-trisodium.html

• Purity:

  99.95

• Solubility:

  H2O : 50 mg/mL (ultrasonic)

• Smiles:

  [Na].O=C(O)CC(O)(C(=O)O)CC(=O)O

• Molecular Weight:

  258.07

• References & Citations:

  [1]Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82.|[2]Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44.|[3]Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20.Insect Biochem Mol Biol. 2023 May 12;103958.|Adv Sci (Weinh). 2024 Oct 30:e2408707.|Carbohydr Polym. 2024 Dec 15:346:122645.|Exp Cell Res. 2020 Aug 1;393(1):112054.|Heliyon. 2024 Jan 17.|J Ethnopharmacol. 2024 Jan 12:117759.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|J Nanobiotechnology. 2023 Oct 19;21(1):383.|Nat Commun. 2024 Sep 10;15(1):7923.|Nature. 2023 Jun;618(7964):374-382.|Phytother Res. 2024 Mar 25.|SSRN. 2024 Mar 20.|Theranostics. 2020 Jul 25;10(21):9477-9494. |Bioengineered. 2021 Dec;12(2):11610-11621.|Biol Trace Elem Res. 2023 May 8.|Biomed Pharmacother. 2023 Aug 18;166:115333.|Drug Des Devel Ther. 2024 Feb 1:18:259-275.|Front Immunol. 2024 Oct 1:15:1397727.|Front Mol Biosci. 22 July 2022.|Int J Biol Sci. 2024 Aug 6;20(11):4222-4237.|Oxid Med Cell Longev. 2022 Apr 25;2022:3846217.|Research Square Preprint. 2021 Jul.|Food Chem. 2022: 134807.|Nature. 2024 Dec 18.|New J Chem. 03 Aug 2022.|J Virol. 2023 Jun 22;e0051223.|Regen Biomater. 2024 Aug 22:11:rbae098.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature, keep dry and cool

• Clinical Information:

  Phase 4

• CAS Number:

  68-04-2