6-Phosphogluconic acid

6-Phosphogluconic acid

• CAS Number: 921-62-0
• UNSPSC Description: 6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid is an endogenous metabolite[1][2].
• Target Antigen: Endogenous Metabolite
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/6-phosphogluconic-acid.html
• Solubility: 10 mM in DMSO
• Smiles: OC([C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O)=O
• Molecular Weight: 276.14
• References & Citations: [1]Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52.|[2]Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported