SDF-1 alpha (CXCL12)

• Description:

  Stromal cell-derived factor (SDF) -1 alpha and SDF-1 beta are the first cytokines initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. They are encoded by a single gene, PBSF, and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the carboxy-terminus of SDF-1 beta and absent from SDF-1 alpha. SDF-1/PBSF is highly conserved between species. Human mature SDF-1 shares approximately 99% amino acid sequence identity with the mouse protein.

• Synonyms:

  Cxcl12; Sdf1

• NCBI Gene ID:

  24772

• UniProt:

  Q9QZD1

• Accession Number:

  NP_071513.1

• Accession Number mRNA:

  NM_022177.3

• Chromosomal Location:

  4q42.1

• Reactivity:

  Rat

• Cross Reactivity:

  Human

• Sequence:

  KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNK

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 50.0-100.0 ng/ml.

• Length:

  68

• Form:

  Lyophilized

• Molecular Weight:

  7.9 kDa

• Host or Source:

  E. coli