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SDF-1 gamma (CXCL12)

CAT: 0209-100-449-L100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-100-449-L100Size:100 µg
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Description
The SDF‐1 proteins are stromal‐derived CXC chemokines that signal primarily through the CXCR4 receptor. SDF‐1 proteins exert chemotactic activity over a broad range of immune system cell types and may also be involved in other processes including metastasis of certain cancers, inflammation, and angiogenesis. Additionally, SDF‐1 can suppress HIV entry into cells expressing the CXCR4 receptor. Five isomers of SDF‐1 have been found with SDF‐1α being the predominant form, expressing in a wide range of cell types. The SDF‐1γ isoform is distinctive in that it contains a highly basic C‐terminal region, which presumably is the reason for its high binding affinity to gylcosaminoglycans (GAG) and heparin sulfate (HS) . Consequently, most of SDF‐1γ exists in a cell‐ and membrane‐bound form, which confers greater stability compared to other isoforms via increased resistance to proteolytic degradation. SDF‐1γ binds with reduced affinity to the CXCR4 receptor when compared to the α and β isoforms, but because of its increased stability can, over time, exert equal or greater activity when compared to other SDF‐1 isoforms. SDF‐1γ expression has been found primarily in the heart (human and mouse) and in the brain and central nervous system (rat) . Recombinant Human SDF‐1γ (CXCL12) is an 11.6 kDa protein containing 98 amino acid residues.
Synonyms
Stromal-Cell Derived Factor-1, PBSF
NCBI Gene ID
6387
UniProt
P48061
Accession Number
NP_000600.1
Accession Number mRNA
NM_000609.7
Chromosomal Location
10q11.21
Reactivity
Human
Cross Reactivity
Human
Sequence
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKGR REEKVGKKEK IGKKKRQKKR KAAQKRKN
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to chemoattract human T cells.
Length
98
Form
Lyophilized
Molecular Weight
11.6 kDa
Host or Source
E. coli

UniProtKB · P48061

Stromal cell-derived factor 1

SDF1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P48061
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CXCL12
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SDF-1, hSDF-1
EC number
—
Processing
Precursor
Secondary accessions
B2R4G0, E7EVL0, H7BYN8, Q2L985, Q2L986, Q2L988, Q5IT36, Q6ICW0, Q9H554
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ChemotaxisHost-virus interaction

Molecular function

CytokineGrowth factor

PTM

Disulfide bond

Cellular component

Secreted

Domain

Signal

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