RANTES (CCL 5)

• Description :

  RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV) . Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

• Synonyms :

  CCL5; SISd; SCYA5; RANTES; TCP228; D17S136E

• NCBI Gene ID :

  6352

• UniProt :

  P13501

• Accession Number :

  NP_002976.2

• Accession Number mRNA :

  NM_002985

• Chromosomal Location :

  17q11.2-q12

• Reactivity :

  Human

• Cross Reactivity :

  Cow, Hamster, Monkey, Mouse, Rat, Human, Leech, Bacteria

• Sequence :

  SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract human blood monocytes using a concentration range of 1.0-10.0 ng/ml.

• Length :

  68

• Form :

  Lyophilized

• Molecular Weight :

  7.8 kDa

• Host or Source :

  E. coli