Products for Research Use Only
RegisterLogin

CCL-12 (MCP-5)

CAT: 0209-103-M322Size: 50 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0209-103-M322Size:50 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CCL12 is a cloned mouse CC chemokine most closely related to human MCP1 (66% amino acid (aa) sequence identity in the mature protein) . Mouse CCL12 encodes a 104 aa residue precursor protein with a 22 aa residue predicted hydrophobic signal sequence that is cleaved to generate a 82 aa residue mature protein. CCL12 is expressed constitutively in the thymus and lymph nodes. Under inflammatory conditions, CCL12 expression is also induced in activated macrophages and mast cells. The gene for mouse MCP1 has been mapped to the CC chemokine cluster on chromosome 11. Recombinant CCL12 has been shown to be a potent chemoattractant for monocytes and lymphocytes but not neutrophils. At high concentrations, CCL12 will also chemoattract eosinophils. CCL12 has been found to be a functional ligand for CCR2 but not CCR1, CCR3, or CCR5.
Synonyms
Ccl12; MCP-5; Scya12
NCBI Gene ID
20293
UniProt
Q62401
Accession Number
NP_035461
Accession Number mRNA
NM_011331.2
Chromosomal Location
11 C; 11 47.0 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant mouse CCL-12
Clone
(#8J25)
Applications
WB, N
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

UniProtKB · Q62401

C-C motif chemokine 12

CCL12_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q62401
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Ccl12
Protein existence
2: Evidence at transcript level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q9QYD6
Protein keywords

Biological process

ChemotaxisInflammatory response

Molecular function

Cytokine

PTM

Disulfide bond

Technical term

Reference proteome

Cellular component

Secreted

Domain

Signal

Related Products

CatalogName
101-M276CCL-8 (MCP-2)
101-M257CCL-13 (MCP-4)
101-M275CCL-7 (MCP-3)
101-M274CCL-5
103-M335CCL-5
R20-012-L500RANTES (CCL 5)
100-095-L1000RANTES (CCL 5)
100-095-L500RANTES (CCL 5)
100-095-L250RANTES (CCL 5)
100-095-L100RANTES (CCL 5)

Alternative Products

CatalogName
mAP-0169Rat Monoclonal anti-mouse CCL-12 (MCP-5)
GTR18090040Rat Monoclonal mouse CCL-12 (MCP-5) Antibody
216183CCL-12 (MCP-5, Chemokine C-C Motif Ligand 12)
SEKCN-0169-01Chicken CCL/MCP-1
GTR18090665Mouse Monoclonal human CCL-2 (MCP-1) Antibody
GTR18090037Rat Monoclonal mouse CCL-2 (MCP-1) Antibody
hAP-0156Mouse Monoclonal anti-human CCL-7 (MCP-3)
hAP-5704Sheep Polyclonal anti-Human CCL-13 (MCP-4)
hAP-5073Sheep Polyclonal anti-human CCL-2 (MCP-1)
hAP-0144Mouse Monoclonal anti-human CCL-2 (MCP-1)

Popular Products